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2016

Publications 2016

Armbruster D, Müller-Alcazar A, Strobel A, Lesch KP, Kirschbaum C, Brocke B (2016) BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children. Psychoneuroendocrinology 66:39-46

Gross-Lesch S, Dempfle A, Reichert S, Jans T, Geissler J, Kittel-Schneider S, Nguyen TT, Reif A, Lesch KP, Jacob CP (2015) Sex- and subtype-related differences in the comorbidity of adult ADHD. J Atten Disord 20:855-866

Thapar A, Martin J, Mick E, Arias Vásquez A, Langley K, Scherer SW, Schachar R, Crosbie J, Williams N, Franke B, Elia J, Glessner J, Hakonarson H; IMAGE 2 Consortium: Freitag CM, Gill M, Anney R, Kent L, Middleton F, Zhang-James Y, Liu L, Meyer J, Nguyen TT, Romanos J, Romanos M, Seitz C, Renner TJ, Walitza S, Warnke A, Palmason H, Buitelaar J, Franke B, Rommelse N, Sergeant J, Steinhausen HC, Roeyers H, Biederman J, Zaharieva I, Lionel AC, Marshall CR, Todorov A, Smalley SL, Loo S, Nelson S, Shtir C, Asherson P, Kuntsi J, Reif A, Lesch KP, McGough J, Owen MJ, Faraone SV, O'Donovan MC, Holmans P (2016) Psychiatric gene discoveries shape evidence on ADHD's biology. Mol Psychiatry 21:1202-1207

Wolf K, Braun A, Haining EJ, Tseng YL, Kraft P, Schuhmann MK, Gotru SK, Chen W, Hermanns HM, Stoll G, Lesch KP, Nieswandt B (2016) Partially defective store operated calcium entry and Hem(ITAM) signaling in platelets of serotonin transporter deficient mice. PLoS One11:e0147664.

Conzelmann A, Woidich E, Mucha RF, Weyers P, Müller M, Lesch KP, Jacob CP, Pauli P (2016) Methylphenidate and emotional-motivational processing in attention-deficit/hyperactivity disorder. J Neural Transm 123:971-979

Song NN, Jia YF, Zhang L, Zhang Q, Huang Y, Liu XZ, Hu L, Lan W, Chen L, Lesch KP, Chen X, Xu L, Ding YQ (2016) Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Sci Rep 6:20338

Strekalova T, Costa-Nunes JP, Veniaminova E, Kubatiev A, Lesch KP, Chekhonin VP, Evans MC, Steinbusch HW (2016) Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. J Affect Disord 196:109-116

Brevik EJ, van Donkelaar MM, Weber H, Sánchez-Mora C, Jacob C, Rivero O, Kittel-Schneider S, Garcia-Martínez I, Aebi M, van Hulzen K, Cormand B, Ramos-Quiroga JA; IMAGE Consortium, Lesch KP, Reif A, Ribasés M, Franke B, Posserud MB, Johansson S, Lundervold AJ, Haavik J, Zayats T (2016) Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 171:733-747

Mooney MA, McWeeney SK, Faraone S, Hinney A, Hebebrand J; IMAGE2 Consortium; German ADHD GWAS Group, Lesch KP, Nigg JT, Wilmot B (2016) Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach. Am J Med Genet B Neuropsychiatr Genet 171:815-826

Morozova A, Zubkov E, Strekalova T, Kekelidze Z, Storozeva Z, Schroeter CA, Bazhenova N, Lesch KP, Cline BH, Chekhonin V (2016) Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats. Prog Neuropsychopharmacol Biol Psychiatry 68:52-63

Ziegler C, Richter J, Mahr M, Gajewska A, Schiele MA, Gehrmann A, Schmidt B, Lesch KP, Lang T, Helbig-Lang S, Pauli P, Kircher T, Reif A, Rief W, Vossbeck-Elsebusch AN, Arolt V, Wittchen HU, Hamm AO, Deckert J, Domschke K (2016) MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy. Transl Psychiatry 6:e773

Freitag CM, Lempp T, Nguyen TT, Jacob CP, Weissflog L, Romanos M, Renner TJ, Walitza S, Warnke A, Rujescu D, Lesch KP, Reif A (2016) The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits. J Neural Transm 123:849-858

Reuter I, Knaup S, Romanos M, Lesch KP, Drepper C, Lillesaar C (2016) Developmental exposure to acetaminophen does not induce hyperactivity in zebrafish larvae. J Neural Transm 123:841-848

Couch Y, Trofimov A, Markova N, Nikolenko V, Steinbusch HW, Chekhonin V, Schroeter C, Lesch KP, Anthony DC, Strekalova T (2016) Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice. J Neuroinflammation 13:108

Demontis D, Lescai F, Børglum A, Glerup S, Østergaard SD, Mors O, Li Q, Liang J, Jiang H, Li Y, Wang J, Lesch KP, Reif A, Buitelaar JK, Franke B (2016) Whole-Exome Sequencing Reveals Increased burden of rare functional and disruptive variants in candidate risk genes in individuals with persistent attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 55:521-523

Meyer N, Richter SH, Schreiber RS, Kloke V, Kaiser S, Lesch KP, Sachser N (2016) The unexpected effects of beneficial and adverse social experiences during adolescence on anxiety and aggression and their modulation by genotype. Front Behav Neurosci 10:97

Prelog M, Hilligardt D, Schmidt CA, Przybylski GK, Leierer J, Almanzar G, El Hajj N, Lesch KP, Arolt V, Zwanzger P, Haaf T, Domschke K (2016) Hypermethylation of FOXP3 promoter and premature aging of the immune system in female patients with panic disorder? PLoS One 11:e0157930

Grünewald L, Landaas ET, Geissler J, Weber H, Quast C, Röh S, Schartner C, Lesch KP, Romanos M, Kittel-Schneider S, Binder E, Reif A (2016) Functional impact of an ADHD-associated DIRAS2 promoter polymorphism. Neuropsychopharmacol 41:3025-3031

Frey A, Saxon VM, Popp S, Lehmann M, Mathes D, Pachel C, Hofmann U, Ertl G, Lesch KP, Frantz S (2016) Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction. J Mol Cell Cardiol 98:28-36

Strekalova T, Markova N, Shevtsova E, Zubareva O, Bakhmet A, Chekhonin V, Steinbusch HM, Bachurin S, Lesch KP (2016) Individual differences in behavioural despair predicts brain GSK-3beta expression in mice: the power of a modified swim test. Neural Plasticity 2016:5098591

Enge S, Fleischhauer M, Gaertner A, Reif A, Lesch KP, Kliegel M, Strobel A (2016) Brain-derived neurotrophic factor (Val66Met) and serotonin transporter (5-HTTLPR) polymorphisms modulate plasticity in inhibitory control performance over time but independent of inhibitory control training. Front Hum Neurosci 10:370

Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister AJ, Galesloot TE, Kiemeney LA, Weber H, Kittel-Schneider S, Lesch KP, Reif A, Ribasés M, Ramos-Quiroga JA, Cormand B, Zayats T, Hegvik TA, Jacobsen KK, Johansson S, Haavik J, Mota NR, Bau CH, Grevet EH, Doyle A, Faraone SV, Arias-Vásquez A, Franke B (2016) Meta-analysis of the DRD5 VNTR in persistent ADHD. Eur Neuropsychopharmacol 26:1527-1532

Leibold NK, van den Hove DL, Viechtbauer W, Buchanan GF, Goossens L, Lange I, Knuts I, Lesch KP, Steinbusch HW, Schruers KR (2016) CO2 exposure as translational cross-species experimental model for panic. Transl Psychiatry 6:e885

Zayats T, Jacobsen KK, Kleppe R, Jacob CP, Kittel-Schneider S, Ribasés M, Ramos-Quiroga JA, Richarte V, Casas M, Mota NR, Grevet EH, Klein M, Corominas J, Bralten J, Galesloot T, Vasquez AA, Herms S, Forstner AJ, Larsson H, Breen G, Asherson P, Gross-Lesch S, Lesch KP, Cichon S, Gabrielsen MB, Holmen OL, Bau CH, Buitelaar J, Kiemeney L, Faraone SV, Cormand B, Franke B, Reif A, Haavik J, Johansson S (2016) Exome chip analyses in adult attention deficit hyperactivity disorder. Transl Psychiatry 6:e923

Jacob CP, Gross-Lesch S, Reichert S, Geissler J, Jans T, Kittel-Schneider S, Nguyen TT, Romanos M, Reif A, Dempfle A, Lesch KP (2016) Sex- and subtype-related differences of personality disorders (axis II) and personality traits in persistent ADHD. J Atten Disord 20:1056-1065

Neufang S, Akhrif A, Herrmann CG, Drepper C, Homola GA, Nowak J, Waider J, Schmitt AG, Lesch KP, Romanos M (2016) Serotonergic modulation of 'waiting impulsivity' is mediated by the impulsivity phenotype in humans. Transl Psychiatry 6:e940

Lesch KP (2016) Editorial: Maturing insights into the genetic architecture of neurodevelopmental disorders - from common and rare variant interplay to precision psychiatry. J Child Psychol Psychiatry 57:659-661