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Publikationen 2015

Publications 2015

Kittel-Schneider S, Reuß M, Meyer A, Weber H, Gessner A, Leistner C, Kopf J, Schmidt B, Hempel S, Volkert J, Lesch KP, Reif A (2014) Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD. J Psychopharmacol 29:31-38

Laas K, Reif A, Akkermann K, Kiive E, Domschke K, Lesch KP, Veidebaum T, Harro J (2015) Neuropeptide S receptor gene variant and environment: Contribution to alcohol use disorders and alcohol consumption. Addict Biol 20:605-616

Domschke K, Tidow N, Schwarte K, Ziegler C, Lesch KP, Deckert J, Arolt V, Zwanzger P, Baune BT (2015) Pharmacoepigenetics of depression – no major influence of MAO-A DNA methylation on treatment response. J Neural Transm 122:99-108 IF 3.0

Strekalova T, Evans M, Chernopiatko A, Couch Y, Costa-Nunes J, Cespuglio R, Chesson L, Vignisse J, Steinbusch HW, Anthony DC, Pomytkin I, Lesch KP (2015) Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism. Behav Brain Res 277:237-244

Schwarz R, Reif A, Scholz CJ, Weissflog L, Schmidt B, Lesch KP, Jacob C, Reichert S, Heupel J, Volkert J, Kopf J, Hilscher M, Weber H, Kittel-Schneider S (2015) A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients. World J Biol Psychiatry 16:180-189

Jacob CP, Gross-Lesch S, Reichert S, Geissler J, Jans T, Kittel-Schneider S, Nguyen TT, Romanos M, Reif A, Dempfle A, Lesch KP (2015) Sex- and subtype-related differences of personality disorders (axis II) and personality traits in persistent ADHD. J Atten Disord, Feb 7 [Epub ahead of print]

Gross-Lesch S, Dempfle A, Reichert S, Jans T, Geissler J, Kittel-Schneider S, Nguyen TT, Reif A, Lesch KP, Jacob CP (2015) Sex- and Subtype-Related Differences in the Comorbidity of Adult ADHDs. J Atten Disord, Nov 6, [Epub ahead of print]

Sánchez-Mora C, Ramos-Quiroga JA, Bosch R, Corrales M, Garcia-Martinez I, Nogueira M, Pagerols M, Palomar G, Richarte V, Vidal R, Arias-Vasquez A, Bustamante M, Forns J, Gross-Lesch S, Guxens M, Hinney A, Hoogman M, Jacob C, Jacobsen KK, Kan C, Kiemeney L, Kittel-Schneider S, Klein M, Onnink M, Rivero O, Zayats T, Buitelaar J, Faraone SV, Franke B, Haavik J, Johansson S, Lesch KP, Reif A, Sunyer J, Bayés M, Casas M, Cormand B, Ribasés M (2015) Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. Neuropsychopharmacol 40:915-926

Igari M, Shen HW, Hagino Y, Fukushima S, Kasahara Y, Lesch KP, Murphy DL, Hall FS, Uhl GR, Ikeda K, Yaegashi N, Sora I (2015) Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behav Pharmacol 26:167-79

Gutknecht L, Popp S, Waider J, Sommerlandt FMJ, Göppner C, Post A, Reif A, van den Hove D, Strekalova T, Schmitt A, Colaco MBN, Sommer C, Palme R, Lesch KP (2015) Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacol 232:2429-2441

Ziegler C, Dannlowski U, Bräuer D, Stevens S, Laeger I, Wittmann H, Kugel H, Dobel C, Hurlemann R, Reif A, Lesch KP, Heindel W, Kirschbaum C, Arolt V, Gerlach AL, Hoyer J, Deckert J, Zwanzger P, Domschke K (2015) Oxytocin receptor gene methylation - converging multi-level evidence for a role in social anxiety. Neuropsychopharmacol 40:1528-1538

Kästner N, Richter SH, Lesch KP, Schreiber RS, Kaiser S, Sachser N (2015) Benefits of a "vulnerability gene"? A study in serotonin transporter knockout mice. Behav Brain Res 283:116-120

Bulayeva K, Lesch KP, Bulayev O, Walsh C, Glatt S, Gurgenova F, Omarova J, Berdichevets I, Thompson PM (2015) Genomic structural variants are linked with intellectual disability. J Neural Transm, Jan 28 [Epub ahead of print]

Maier R, Moser G, Chen GB, Ripke S; Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Absher D, Agartz I, Akil H, ..., Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, ..., Zandi PP, Zhang P, Zitman FG, Zöllner S, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH; (2015) Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Am J Hum Genet 96:283-294

Strekalova T, Evans M, Costa-Nunes J, Bachurin S, Yeritsyan N, Couch Y, Steinbusch HM, Köhler ES, Lesch KP, Anthony DC (2015) Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet. Brain Behav Immun 48:42-47

Laas K, Eensoo D, Paaver M, Lesch KP, Reif A, Harro J (2015) Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn107Ile) with impulsivity and hyperactivity. J Psychopharmacol 29:878-883

The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium; O’Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM, ..., Lawson WB, Leboyer M, Ledbetter DH, Lencz T, Lesch KP,  DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, …, Craddock N, Kendler KS, Weiss LA, Wray NR, Zhao Z, Geschwind DH, Sullivan PF, Smoller JW, Holmans PA, Breen G (2015) Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 18:199-209

Bodden C, Richter SH, Schreiber RS, Kloke V, Gerß J, Palme R, Lesch KP, Lewejohann L, Kaiser S, Sachser N (2015) Benefits of adversity?! How life history affects the behavioral profile of mice varying in serotonin transporter genotype. Front Behav Neurosci 9:47

Cline BH, Costa-Nunes JP, Cespuglio R, Markova N, Santos AI, Bukhman YV, Kubatiev A, Steinbusch HW, Lesch KP, Strekalova T (2015) Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression. Front Behav Neurosci 9:37

Juhasz G, Gonda X, Hullam G, Eszlari N, Kovacs D, Lazary J, Pap D, Petschner P, Elliott R, Deakin JF, Anderson IM, Antal P, Lesch KP, Bagdy G (2015) Variability in the effect of 5-HTTLPR on depression in a large European population: the role of age, symptom profile, type and intensity of life stressors. PLoS One 10:e0116316

Piao YS, Hall FS, Moriya Y, Ito M, Ohara A, Kikura-Hanajiri R, Goda Y, Lesch KP, Murphy DL, Uhl GR, Sora I (2015)  Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Behav Pharmacol 26:345-352

Hommers L, Raab A, Bohl A, Weber H, Scholz CJ, Erhardt A, Binder E, Arolt V, Gerlach A, Gloster A, Kalisch R, Kircher T, Lonsdorf T, Ströhle A, Zwanzger P, Mattheisen M, Cichon S, Lesch KP, Domschke K, Reif A, Lohse MJ, Deckert J (2015) MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits. Am J Med Genet B Neuropsychiatr Genet 168B:296-306

Rivero O, Selten M, Sich S, Popp S, Bacmeister L, Amendola E, Negwer M, Schubert D, Proft F, Kiser D, Schmitt A, Gross C, Kolk SM, Strekalova T, van den Hove D, Resink TJ, Nadif Kasri N, Lesch KP (2015) Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition. Transl Psychiatry 5:e655

Armbruster D, Müller-Alcazar A, Strobel A, Lesch KP, Kirschbaum C, Brocke B (2015) BDNF val66met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children. Psychoneuroendocrinology 66:39-46
Kiser DP, Rivero O, Lesch KP (2015) The (epi)genetics of neurodevelopmental disorders in the era of whole-genome sequencing: unveiling the dark matter. J Child Psychol Psychiatry 56:278-295

Leibold NK, van den Hove DL, Esquivel G, De Cort K, Goossens L, Strackx E, Buchanan GF, Steinbusch HW, Lesch KP, Schruers KR (2015) The brain acid-base homeostasis and serotonin: a perspective on the use of carbon dioxide as human and rodent experimental model of panic. Prog Neurobiol 129:58-78

Lesch KP  (2015) Editorial: Attention-deficit/hyperactivity disorder: a continuing challenge to researchers, practitioners and carers. J Child Psychol Psychiatry 56:595-597

Blum R, Lesch KP (2015) Parkinson's disease, anxious depression and serotonin - zooming in on hippocampal neurogenesis. J Neurochem 135:441-444

Hammels C, Pishva E, De Vry J, van den Hove DL, Prickaerts J, van Winkel R, Selten JP, Lesch KP, Daskalakis NP, Steinbusch HW, van Os J, Kenis G, Rutten BP (2015) Defeat stress in rodents: From behavior to molecules. Neurosci Biobehav Rev 59:111-140