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Publikationen 2012

2012

Pryce C, Azzinnari D, Sigrist H, Gschwind T, Lesch KP, Seifritz E (2012) Establishing a learned-helplessness effect paradigm in C57BL/6 mice: behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se. Neuropharmacol 62:358-372

Jennings KA, Licht CL, Bruce A, Lesch KP, Knudsen GM, Sharp T (2012) Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT4 receptor levels. Int J Neuropsychopharmacol 15:1099-1107

Hahn T, Dresler T, Ehlis AC, Pyka M, Dieler AC, Saathoff C, Jakob PM, Lesch KP, Fallgatter AJ (2012) Randomness of resting-state brain oscillations encodes Gray's personality trait. Neuroimage 59:1842-1845

Jain M, Vélez JI, Acosta MT, Palacio LG, Balog J, Roessler E, Pineda D, Londoño AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Castellanos FX, Bailey-Wilson JE, Arcos-Burgos M, Muenke M (2012 A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD. Mol Psychiatry 17:741-747

Müller A, Strahler J, Armbruster D, Lesch KP, Brocke B, Kirschbaum C (2012) Genetic contributions to acute autonomic stress responsiveness in children. Int J Psychophysiol 83:302-308

Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Sleiman PMA, Zhang H, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Cara Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen HC, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch KP, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Biederman J, Kent L, Asherson P, Anney R, Gaynor JW, Shaw P, Devoto M, Grant SFA, White P, Buxbaum JD, Rapoport JL, Williams NM, Nelson SF, Faraone SV, Hakonarson H (2012) Genome wide copy number variation study associates metabotropic glutamate receptor genes with attention deficit hyperactivity disorder. Nat Genetics 44:78-84

Armbruster D, Müller A, Strobel A, Lesch KP, Brocke B, Kirschbaum C (2012) Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm. Int J Neuropsychopharmacol 15:1229-1239

Stergiakouli E, Hamshere M, Holmans P, Langley K, Zaharieva I; deCODE Genetics; Psychiatric GWAS Consortium: Faraone SV, Neale BM, Ripke S, Daly M, Medland SE, Asherson P, Franke B, Steinhausen HC, Lesch KP, Freitag C, Reif A, Renner TJ, Nguyen TT, Romanos M, Romanos J, Walitza S, Schäfer H, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Anney RJ, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein R, Rothenberger A, Banaschewski T, Oades R, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S.; Hawi Z, Kent L, Gill M, Williams N, Owen MJ, O'Donovan M, Thapar A (2012) Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. Am J Psychiatry 169:186-194

Williams NM, Franke B, Mick E, Anney RJ, Freitag CM, Gill M, Thapar A, O'Donovan MC, Owen MJ, Holmans P, Kent L, Middleton F, Zhang-James Y, Liu L, Meyer J, Nguyen TT, Romanos J, Romanos M, Seitz C, Renner TJ, Walitza S, Warnke A, Palmason H, Buitelaar J, Rommelse N, Vasquez AA, Hawi Z, Langley K, Sergeant J, Steinhausen HC, Roeyers H, Biederman J, Zaharieva I, Hakonarson H, Elia J, Lionel AC, Crosbie J, Marshall CR, Schachar R, Scherer SW, Todorov A, Smalley SL, Loo S, Nelson S, Shtir C, Asherson P, Reif A, Lesch KP, Faraone SV (2012) Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry 169:195-204

Ribasés M, Ramos-Quiroga JA, Hervás A, Sánchez-Mora C, Bosch R, Bielsa A, Gastaminza X, Lesch KP, Reif A, Renner TJ, Romanos M, Warnke A, Walitza S, Freitag C, Meyer J, Palmason H, Casas M, Bayés M (2012) Cormand B. Candidate system analysis in ADHD: Evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. World J Biol Psychiatry 13:281-292

Lange M, Norton W, Coolen M, Chaminade M, Merker S, Proft F, Schmitt A, Vernier P, Lesch KP, Bally-Cuif L (2012) The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Mol Psychiatry 17:946-954

Ribasés M, Sánchez-Mora C, Ramos-Quiroga JA, Bosch R, Gómez N, Nogueira M, Corrales M, Palomar G, Jacob CP, Gross-Lesch S, Kreiker S, Reif A, Lesch KP, Cormand B, Casas M, Bayés M (2012) An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples. Psychiatr Genet 22(4):155-160

Kittel-Schneider S, Kenis G, Schek J, van den Hove D, Prickaerts J, Lesch KP, Steinbusch H, Reif A (2012) Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes. Front Psychiatry 3:33.

Bonn M, Schmitt A, Lesch KP, Van Bockstaele EJ, Asan E (2012) Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei. Brain Struct Funct, Apr 17 [Epub ahead of print]

Grünblatt E, Geißler J, Jacob CP, Renner T, Müller M, Bartl J, Gross-Lesch S, Riederer P, Lesch KP, Walitza S, Gerlach M, Schmitt A (2012) Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood. Atten Defic Hyperact Disord 4:77-84

Anacker K, Enge S, Reif A, Lesch KP, Strobel A (2012)  Dopamine D4 receptor gene variation impacts self-reported altruism. Mol Psychiatry, May 8 [Epub ahead of print] IF 15.5

Heinzel S, Dresler T, Baehne CG, Heine M, Boreatti-Hümmer A, Jacob CP, Renner TJ, Reif A, Lesch KP, Fallgatter AJ, Ehlis AC (2012) COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control. Cereb Cortex May 22 [Epub ahead of print]

Jacob C, Nguyen TT, Weißflog L, Herrmann M, Liedel S, Zamzow K, Jans T, Renner T, Reichert S, Gross-Lesch S, Lesch KP, Reif A (2012) PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD. Atten Defic Hyperact Disord 4:145-152

Conzelmann A, Reif A, Jacob C, Weyers P, Lesch KP, Lutz B, Pauli P (2012) A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity. Psychopharmacology (Berl) 224:573-579

Ineichen C, Sigrist H, Spinelli S, Lesch KP, Sautter E, Seifritz E, Pryce C (2012) Establishing a probabilistic reversal learning test in mice: Evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin. Neuropharmacology 63:1012-1021

Gutknecht L, Araragi N, Merker S, Waider J, Sommerlandt FMJ, Mlinar B, Baccini G, Mayer U, Proft F, Post A, Hamon M, Schmitt AG, Corradetti R, Lanfumey L, Lesch KP (2012) Brain serotonin deficiency following Tph2 inactivation impacts somatic development but not raphe neuron specification. PloS One 7:e43157

Kurrikoff T, Lesch KP, Kiive E, Konstabel K, Herterich S, Veidebaum T, Reif A, Harro J (2012) Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness. Development and Psychopathology 24:1225–1235

Waider J, Proft F, Langlhofer G, Asan E, Lesch KP, Gutknecht L (2012) GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochem Cell Biol, Oct 11 [Epub ahead of print]

Weissflog L, Scholz CJ, Jacob CP, Nguyen TT, Zamzow K, Groß-Lesch S, Renner TJ, Romanos M, Rujescu D, Walitza S, Kneitz S, Lesch KP, Reif A (2012) KCNIP4 as a candidate gene for personality disorders and adult ADHD. Eur Neuropsychopharmacol, Sep 13 [Epub ahead of print]

Hahn T, Marquand AF, Plichta MM, Ehlis AC, Schecklmann MW, Dresler T, Jarczok TA, Eirich E, Leonhard C, Reif A, Lesch KP, Brammer MJ, Mourao-Miranda J, Fallgatter AJ (2012) A novel approach to probabilistic biomarker-based classification using functional near-infrared spectroscopy. Hum Brain Mapp, Jan 16 [Epub ahead of print]

Dentel C, Palamiuc L, Henriques A, Lannes B, Spreux-Varoquaux O, Gutknecht L, Rene F, Echaniz-Laguna A, Gonzalez de Aguilar JL, Lesch KP, Meininger V, Loeffler JP, Dupuis L (2012) Degeneration of serotonin neurons in amyotrophic lateral sclerosis: a link to spasticity. Brain, Oct 31 [Epub ahead of print]

Van den Hove DLA, Kenis G, Brass A, Rutten BPF, Bruschettini M, Blanco CE, Lesch KP, Steinbusch HWM, Prickaerts J (2012) Vulnerability versus resilience to prenatal stress in male versus female Sprague-Dawley rats; implications from gene expression profiles in the hippocampus and frontal cortex. Eur Neuropsychopharmacol, Nov 27 [Epub ahead of print]

Fallgatter AJ Ehlis AC, Dresler T, Reif A, Jacob C, Arcos-Burgos M, Muenke M, Lesch KP (2012) Influence of a Latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit/hyperactivity disorder (ADHD). Eur Neuropsychopharmacology, Dec 11 [Epub ahead of print]

Enge S, Fleischhauer M, Lesch KP, Reif A, Strobel A (2012) Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention. Cereb Cortex, Dec 20 [Epub ahead of print]

Lesch KP, Araragi N, Waider J, van den Hove D, Gutknecht L (2012) Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behavior. Philos Trans R Soc Lond B Biol Sci 367:2426-2443

Lesch KP, Merker S, Reif A, Novak N (2012) Dances with black widow spiders: dysregulation of glutamate signalling enters center stage in ADHD. Eur Neuropsychopharmacol Aug 29, [Epub ahead of print]

Rivero O, Sich S, Popp S, Schmitt A, Franke B, Lesch KP (2012) Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks. Eur Neuropsychopharmacol. Jul 11 [Epub ahead of print]

Lesch KP, Waider J (2012) Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. Neuron 76:175-191

Boulle F, van den Hove DL, Jakob SB, Rutten BP, Hamon M, van Os J, Lesch KP, Lanfumey L, Steinbusch HW, Kenis G (2012) Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry 17:584-596

The International Multicentre persistent ADHD CollaboraTion: Franke B, Faraone SV, Bau C, Grevet E, Ramos-Quiroga JA, Mick E, Johansson S, Haavik J, Buitelaar J, Lesch KP, Cormand B, Asherson P, Reif A (2011) The genetics of Attention Deficit/Hyperactivity Disorder (ADHD) in adults, a review. Mol Psychiatry 17:960-987