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Publikationen 2011

Publications 2011

  1. Enge S, Fleischhauer M, Lesch KP, Strobel A (2011) On the role of serotonin and effort in voluntary attention: evidence of genetic variation in N1 modulation. Behav Brain Res 216:122-128
  2. Hahn T, Heinzel S, Dresler T, Plichta MM, Renner TJ, Markulin F, Jakob PM, Lesch KP, Fallgatter AJ (2011) Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype. Hum Brain Mapp 32:1557-65
  3. Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Shoichet S, Dempfle A, Heine M, Boreatti-Hümmer A, Walitza S, Romanos J, Gross-Lesch S, Zerlaut H, Allolio B, Heinzel S, Fassnacht M, Fallgatter A, Wultsch T, Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R (2011) Genome-wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry 16:491-503
  4. Romanos M, Schecklmann M, Kraus K, Fallgatter A, Warnke A, Lesch KP, Gerlach M (2011) Olfactory deficits in deletion syndrome 22q11.2. Schizophrenia Res 129:220-221
  5. Line SJ, Barkus C, Coyle C, Jennings KA, Deacon RM, Lesch KP, Sharp T, Bannerman DM (2011) Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice. Eur Neuropsychopharmacol 21:108-116
  6. Hoyle D, Juhasz G, Aso E, Chase D, Del Rio J, Fabre V, Hamon M, Lanfumey L, Lesch KP, Maldonado R, Serra MA, Sharp T, Tordera R, Toro C, Deakin JF (2011) Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression. Eur Neuropsychopharmacol 21:3-10
  7. Lazary J, Juhasz G, Anderson IM, Jacob CP, Nguyen TT, Lesch KP, Reif A, Deakin JF, Bagdy G (2011) Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality. Eur Neuropsychopharmacol 21:63-70
  8. Homberg JR, Lesch KP (2011) Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry 69:513-519
  9. Adori C, Lőw P, Andó RD, Gutknecht L, Pap D, Truszka F, Takács J, Kovács GG, Lesch KP, Bagdy G (2011) Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat. Psychopharmacol 213:377-391
  10. Fabre V, Massart R, Rachalski A, Jennings K, Brass A, Sharp T, Lesch KP, Lanfumey L, Hamon M (2011) Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: A focus on urocortin 1. Eur Neuropsychopharmacol 21:33-44
  11. Hahn T, Heinzel S, Plichta MM, Reif A, Lesch KP, Fallgatter AJ (2011) Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant. Cereb Cortex, Nov 19 [Epub ahead of print]
  12. Dawson N, Ferrington L, Lesch KP, Kelly PA (2011) Cerebral metabolic responses to 5-HT(2A/C) receptor activation in mice with genetically modified serotonin transporter (SERT) expression. Eur Neuropsychopharmacol 21:117-128
  13. Post AM, Weyers P, Holzer P, Painsipp E, Pauli P, Wultsch T, Reif A, Lesch KP (2011) Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models. Behav Brain Res 218:99-105
  14. Hall FS, Schwarzbaum JM, Perona MT, Templin JS, Caron MG, Lesch KP, Murphy DL, Uhl GR (2011) A greater role for the norepinephrine transporter than the serotonin transporter in nociception. Neuroscience 175:315-327
  15. Hahn T, Marquand AF, Ehlis AC, Dresler T, Kittel-Schneider S, Jarczok TA, Lesch KP, Jakob PM, Mourao-Miranda J, Brammer MJ, Fallgatter AJ (2011) Integrating neurobiological markers of depression. Arch Gen Psychiatr 68:361-368
  16. Cirulli F, Reif A, Herterich S, Lesch KP, Berry A, Francia N, Aloe L, Barr CS, Suomi SJ, Alleva E (2011) A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques. Psychoneuroendocrinol 36:372-379
  17. Stark R, Bauer E, Merz CJ, Zimmermann M, Reuter M, Plichta MM, Kirsch P, Lesch KP, Fallgatter AJ, Vaitl D, Herrmann MJ (2011) ADHD related behaviors are associated with brain activation in the reward system. Neuropsychologia 49:426-434
  18. Nietzer SL, Bonn M, Jansen F, Heiming R, Lewejohann L, Sachser N, Asan ES*, Lesch KP*, Schmitt AG* (2011) Serotonin transporter knockout and repeated social stress: impact on neuronal morphology and plasticity in limbic brain areas. Behav Brain Res 220:42-54 *equal contribution
  19. Conzelmann A, Woidich E, Mucha RF, Weyers P, Jacob CP, Lesch KP, Pauli P (2011) Methylphenidate normalizes emotional processing in adult patients with attention-deficit/hyperactivity disorder: preliminary findings. Brain Res 1381:159-166
  20. Kas MJ, Krishnan V, Gould TD, Collier DA, Olivier B, Lesch KP, Domenici E, Fuchs E, Gross C, Castrén E (2011) Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders. Eur Neuropsychopharmacol 21:532-544
  21. Ehlis AC, Bauernschmitt K, Dresler T, Hahn T, Herrmann MJ, Röser C, Romanos M, Warnke A, Gerlach M, Lesch KP, Fallgatter AJ, Renner TJ (2011) Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: An event-related potential study. Am J Med Genet B Neuropsychiatr Genet 156B:291-302
  22. Post AM, Wultsch T, Popp S, Painsipp E, Wetzstein H, Kittel-Schneider S, Sontag TA, Lesch KP, Reif A (2011) The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice. Behav Brain Res 220:152-158
  23. Reif A, Schecklmann M, Eirich E, Jacob CP, Jarczok TA, Kittel-Schneider S, Lesch KP, Fallgatter AJ, Ehlis AC (2011) A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia. Int J Neuropsychopharmacol 14:887-897
  24. Jansen F, Heiming RS, Kloke V, Kaiser S, Palme R, Lesch KP, Sachser N (2011) Away game or home match: The influence of venue and serotonin transporter genotype on the display of offensive aggression. Behav Brain Res 219:291-301
  25. Song NN, Xiu JB, Huang Y, Chen JY, Zhang L, Gutknecht L, Lesch KP, Li H, Ding YQ (2011) Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PLoS One 6:e15998
  26. Mueller A, Armbruster D, Moser DA, Canli T, Lesch KP, Brocke B, Kirschbaum C (2011) Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response. Neuropsychopharmacol 36:1332-1339 IF 6.7
  27. Hansen N, Uçeyler N, Palm F, Zelenka M, Biko L, Lesch KP, Gerlach M, Sommer C (2011) Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy. Neurosci Lett 495:93-97
  28. Weiland R, Macht M, Ellgring H, Gross-Lesch S, Lesch KP, Pauli P (2011) Olfactory and gustatory sensitivity in adults with attention-deficit/hyperactivity disorder. Atten Defic Hyperact Disord 3:53-60.
  29. Armbruster D, Mueller A, Strobel A, Lesch KP, Kirschbaum C, Brocke B (2011) Variation in genes involved in dopamine clearance influence the startle response in older adults. J Neural Transm 118:1281-1292
  30. Chen Y, Palm F, Lesch KP, Gerlach M, Moessner R, Sommer C (2011) 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice. Mol Pain 7:21
  31. Armbruster D, Mueller A, Strobel A, Lesch KP, Brocke B, Kirschbaum C (2011) Predicting cortisol stress responses in older individuals: influence of serotonin receptor 1 A gene (HTR1A) and stressful life events. Horm Behav 60:105-111
  32. Adori C, Andó RD, Szekeres M, Gutknecht L, Kovács GG, Hunyady L, Lesch KP, Bagdy G (2011) Recovery and aging of serotonergic fibers after single and intermittent MDMA treatments in Dark Agouti rat. J Comp Neurol 519:2353-2378
  33. Sanchez-Mora C, Ribases M, Casas M, Bayes M, Bosch R, Fernandez-Castillo N, Brunso L, Jacobsen KK, Landaas ET, Lundervold AJ, Gross-Lesch S, Kreiker S, Jacob CP, Lesch KP, Buitelaar JK Hoogman M, Kiemeney LALM, Kooij JJS, Mick E, Asherson P, Faraone SV, Franke B, Reif A, Johansson S, Haavik J, Ramos-Quiroga JA, Cormand B (2011) Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: a meta-analysis in four european populations. Am J Med Genet B Neuropsychiatr Genet 156:600-612
  34. Kloke V, Jansen F, Heiming RS, Palme R, Lesch KP, Sachser N (2011) The winner and loser effect, serotonin transporter genotype, and the display of offensive aggression. Physiol Behav 103:565-574
  35. Rantamäki T, Vesa L, Antila H, Di Lieto A, Tammela P, Schmitt A, Lesch KP, Rios M, Castrén E (2011) Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One 6:e20567
  36. Jahanshahi A, Le Maitre E, Temel Y, Lanfumey L, Hamon M, Lesch KP, Tordera RM, Del Río J, Aso E, Maldonado R, Hökfelt T, Steinbusch HW (2011) Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. J Chem Neuroanat 41:227-233
  37. Van den Hove DLA, Jakob SB, Schraut KG, Kenis G, Schmitt AG, Kneitz S, Scholz CJ, Wiescholleck V, Ortega G, Prickaerts J, Steinbusch HWM, Lesch KP (2011) Sex-specific effects of prenatal stress in 5-HTT deficient mice: towards molecular mechanisms of gene x environment interactions. PloS One 6:e22715
  38. Weber H, Kittel-Schneider S, Gessner A, Domschke K, Neuner M, Jacob CP, Buttenschon HN, Boreatti-Hümmer A, Volkert J, Herterich S, Baune BT, Gross-Lesch S, Kopf J, Kreiker S, Nguyen TT, Weissflog L, Arolt V, Mors O, Deckert J, Lesch KP, Reif A (2011) Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacolol 36:2076-2085
  39. Reif A, Nguyen TT, Weißflog L, Jacob CP, Romanos M, Renner TJ, Buttenschon HN, Kittel-Schneider S, Gessner A, Weber H, Neuner M, Gross-Lesch S, Zamzow K, Kreiker S, Walitza S, Meyer J, Freitag CM, Bosch R, Casas M, Gómez N, Ribasès M, Bayès M, Buitelaar JK, Kiemeney LA, Kooij JJ, Kan CC, Hoogman M, Johansson S, Jacobsen KK, Knappskog PM, Fasmer OB, Asherson P, Warnke A, Grabe HJ, Mahler J, Teumer A, Völzke H, Mors ON, Schäfer H, Ramos-Quiroga JA, Cormand B, Haavik J, Franke B, Lesch KP (2011) DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders. Neuropsychopharmacol 36:2318-2327
  40. Heiming RS, Bodden C, Jansen F, Lewejohann L, Kaiser S, Lesch KP, Palme R, Sachser N (2011) Living in a dangerous world decreases maternal care: A study in serotonin transporter knockout mice. Horm Behav 60:397-407
  41. Hinney A, Scherag A, Jarick I, Albayrak O,Pütter C, Pechlivanis S, Dauvermann MR, Beck S, Weber H, Scherag S, Nguyen TT, Volckmar AL, Knoll N, Faraone SV, Neale BM, Franke B, Cichon S, Hoffmann P, Nöthen MM, Schreiber S, Jöckel KH, Wichmann HE, Freitag C, Lempp T, Meyer J, Gilsbach S, Herpertz-Dahlmann B, Sinzig J, Lehmkuhl G, Renner TJ, Warnke A, Romanos M, Lesch KP, Reif A, Schimmelmann BG, Hebebrand J, Psychiatric GWAS Consortium: ADHD subgroup. (2011) Genome-wide association study in German patients with attention deficit/hyperactivity disorder. Am J Med Genet Part B 156:888-897
  42. Renner TJ, Nguyen TT, Romanos M, Walitza S, Röser C, Reif A, Schäfer H, Warnke A, Gerlach M, Lesch KP (2011) No evidence for association between a functional promoter variant of the Norepinephrine transporter gene SLC6A2 and ADHD in a family-based sample. Atten Defic Hyperact Disord 3:285-289
  43. Enge S, Fleischhauer M, Lesch KP, Reif A, Strobel A (2012) Serotonergic modulation in executive functioning: Linking genetic variations to working memory performance. Neuropsychologia 49:3776-378