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Publikationen 2010

Publications 2010


  1. Brocke B*, Lesch KP*, Armbruster D, Moser DA, Müller A, Strobel A, Kirschbaum C (2010) Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans. Am J Med Genet B Neuropsychiatr Genet 153B:243-251 *equal contribution
  2. Pauli P, Conzelmann A, Mucha R, Weyers P, Baehne CG, Fallgatter AJ, Jacob C, Lesch KP (2010) Affect-modulated startle reflex and dopamine D4 receptor gene variation. Psychophysiology 47:25-33
  3. Müller A, Brocke B, Fries E, Lesch KP, Kirschbaum C (2010) The role of the serotonin transporter polymorphism for the behavioral and endocrine stress response in newborns. Psychoneuroendocrinol 35:289-296
  4. Sánchez-Mora C, Ribasés M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti-Hümmer A, Heine M, Jacob CP, Lesch KP, Fasmer OB, Knappskog PM, Kooij JJ, Kan C, Buitelaar JK, Mick E, Asherson P, Faraone SV, Franke B, Johansson S, Haavik J, Reif A, Bayés M, Cormand B (2010) Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations. Am J Med Genet B Neuropsychiatr Genet 153B:512-523
  5. Jansen F, Heiming RS, Lewejohann L, Touma C, Palme R, Schmitt A, Lesch KP, Sachser N. (2010) Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood. Behav Brain Res 207:21-29
  6. Jacob CP, Nguyen TT, Dempfle A, Heine M, Windemuth-Kieselbach C, Baumann K, Jacob F, Prechtl J, Wittlich M, Herrmann MJ, Gross-Lesch S, Lesch KP, Reif A (2010) A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. Eur Arch Psychiatry Clin Neurosci 260:317-326
  7. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domené S, Vélez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londoño AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M (2010) A common variant of Latrophilin 3 (LPHN3) confers susceptibility to attention-deficit/hyperactivity disorder and predicts effectiveness of stimulant medication. Mol Psychiatry 15:1053-1066
  8. Scholz CJ, Jacob CP, Buttenschon HN, Kittel-Schneider S, Boreatti-Hümmer A, Zimmer M, Walter U, Lesch KP, Mors O, Kneitz S, Deckert J, Reif A (2010) Functional variants of Tspan8 are associated with bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B:967-972
  9. Benninghoff J, Gritti A, Rizzi M, Lamorte G, Schloesser RJ, Schmitt A, Robel S, Genius J, Moessner R, Riederer P, Manji HK, Grunze H, Rujescu D, Moeller HJ, Lesch KP, Vescovi AL (2010) Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells. Neuropsychopharmacology 35:893-903 IF7.0
  10. Bartolomucci A, Carola V, Pascucci T, Puglisi-Allegra S, Cabib S, Lesch KP, Parmigiani S, Palanza P, Gross C (2010) Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Dis Model Mech 3:459-470
  11. Uçeyler N, Schütt M, Palm F, Vogel C, Meier M, Schmitt A, Lesch KP, Mössner R, Sommer C (2010) Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity. Int J Obes (Lond) 34:701-711
  12. Franke B, Vasquez AA, Johansson S, Hoogman M, Romanos J, Boreatti-Hümmer A, Heine M, Jacob CP, Lesch KP, Casas M, Ribasés M, Bosch R, Sánchez-Mora C, Gómez-Barros N, Fernàndez-Castillo N, Bayés M, Halmøy A, Halleland H, Landaas ET, Fasmer OB, Knappskog PM, Heister AJ, Kiemeney LA, Kooij JJ, Boonstra AM, Kan CC, Asherson P, Faraone SV, Buitelaar JK, Haavik J, Cormand B, Ramos-Quiroga JA, Reif A (2010) Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD. Neuropsychopharmacol 35:656-664]
  13. Landaas ET, Johansson S, Jacobsen KK, Ribasés M, Bosch R, Sánchez-Mora C, Jacob CP, Boreatti-Hümmer A, Kreiker S, Lesch KP, Kiemeney LA, Kooij JJ, Kan C, Buitelaar JK, Faraone SV, Halmøy A, Ramos-Quiroga JA, Cormand B, Reif A, Franke B, Mick E, Knappskog PM, Haavik J (2010) An international multicenter association study of the serotonin transporter gene in persistent ADHD. Genes Brain Behav 9:449-458
  14. Romanos M., Ehlis AC, Baehne CG, Jacob C, Renner TJ, Storch A, Briegel W, Walitza S, Lesch KP, Fallgatter A (2010) Reduced NoGo-anteriorization during continuous performance test in Deletion Syndrome 22q11.2. J Psychiatric Res 44:768-774
  15. Laas K, Reif A, Herterich S, Eensoo D, Lesch KP, Harro J (2010) The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity. Psychopharmacol 209:255-261
  16. Armbruster D, Müller A, Strobel A, Kirschbaum C, Lesch KP, Brocke B (2010) Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biol Psychol 83:214-221
  17. Kriegebaum CB, Gutknecht L, Bartke, L, Reif A, Buttenschon HN, Mors O, Lesch KP, Schmitt AG (2010) The expression of the transcription factor FEV in adult human brain and its association with affective disorders. J Neural Transm 117:831-836
  18. Lewejohann L, Kloke V, Heiming RS, Jansen F, Kaiser S, Schmitt A, Lesch KP, Sachser N (2010) Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behav Brain Res 211:220-228
  19. Dresler T, Ehlis AC, Heinzel S, Renner TJ, Reif A, Baehne CG, Heine M, Boreatti-Hümmer A, Jacob JP, Lesch KP, Fallgatter AJ (2010) Dopamine transporter (DAT) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD. Neuropsychopharmacol 35:2193-202
  20. Reif A, Kiive E, Kurrikoff T, Paaver M, Herterich S, Konstabel K, Tulviste T, Lesch KP, Harro J (2010) A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity. Psychopharmacol, Jun30 [Epub ahead of print]
  21. Hahn T, Dresler T, Plichta MM, Ehlis AC, Ernst LH, Markulin F, Polak T, Blaimer M, Deckert J, Lesch KP, Jakob PM, Fallgatter AJ (2010) Functional amygdala-hippocampus connectivity during anticipation of aversive events is associatied with Gray´s trait "sensitivity to punishment". Biol Psychiatry 68:459-464
  22. Johansson S, Halmoy A, Mavroconstanti T, Jacobsen KK, Landaas ET, Reif A, Jacob C, Boreatti-Hümmer A, Kreiker S, Lesch KP, Kan CC, Kooij JJ, Kiemeney LA, Buitelaar JK, Franke B, Ribasés M, Bosch R, Bayés M, Casas M, Ramos-Quiroga JA, Cormand B, Knappskog P, Haavik J (2010) Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. Am J Med Genet B Neuropsychiatr Genet 153B:1008-1015
  23. Kriegebaum C, Song NN, Gutknecht L, Huang Y, Schmitt A, Reif A, Ding YQ, Lesch KP (2010) Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal sertonergic gene expression in the absence of serotonin during adult life. Neurochem Int 57:512-517
  24. Conzelmann A, Pauli P, Mucha RF, Jacob CP, Gerdes AB, Romanos J, Bähne CG, Heine M, Boreatti-Hümmer A, Alpers GW, Fallgatter AJ, Warnke A, Lesch KP, Weyers P (2010) Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults. J Abnorm Psycho 119:594-603
  25. Neale BM, Medland S, Ripke S, Anney RJ, Asherson P, Buitelaar J, Franke B, Gill M, Kent L, Holmans P, Middleton F, Thapar A, Lesch KP, Faraone SV, Daly M, Nguyen TT, Schäfer H, Steinhausen HC, Reif A, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Freitag C, Meyer J, Palmason H, Rothenberger A, Hawi Z, Sergeant J, Roeyers H, Mick E, Biederman J; IMAGE II Consortium (2010) Case-control genome-wide associations study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:906-920
  26. Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch KP, Faraone SV, Nguyen TT, Schäfer H, Holmans P, Daly M, Stenhausen HC, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJ, Langely K, O´Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biedermann J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschweski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S; Psychiatric GWAS Consortium: ADHD Subgroup (2010) Meta-Analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:884-897
  27. Rivero O, Reif A, Sanjuán J, Motó MD, Kittel-Schneider S, Nájera C, Töpner T, Lesch KP (2010) Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study. PLoS One 5:e12254
  28. Jennings K, Lesch KP, Sharp T, Cragg S (2010) Non-linear relationship between 5HT transporter gene expression and frequency sensitivity of 5-HT signals. J Neurochem 115:965-973