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Publikationen 2007

Publications 2007


  1. Gutknecht L, Jacob C, Strobel A, Müller J, Reif A, Mössner R, Zeng Y, Gross C, Brocke B, Lesch KP (2007) Tryptophan hydroxylase-2 gene variation influences personality traits and related disorders. Int J Neuropsychopharmacol 10:309-320

  2. Fallgatter AJ, Lesch KP (2007) 22q11.2 deletion syndrome as a natural model for COMT haploinsufficiency-related dopaminergic dysfunction in ADHD. Int J Neuropsychopharmacol 10:295-299

  3. Altamura C, Dell’Acqua ML, Moessner R, Murphy DL, Lesch KP, Persico A.M (2007) Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cerebral Cortex 17:1394-1401

  4. Ehlis AC, Reif A, Herrmann MJ, Lesch KP, Fallgatter AJ (2007) Impact of catechol-O-methyltransferase  genotype on prefrontal brain functioning in schizophrenia spectrum disorders. Neuropsychopharmacology 32:162-170

  5. Hohoff C, Marziniak M, Lesch KP, Deckert J, Sommer C, Mössner R (2007) An adenosine A(2A) receptor gene haplotype is associated with migraine with aura. Cephalalgia 27:177-181

  6. Herrmann MJ, Huter T, Müller F, Mühlberger A, Pauli P, Reif A, Canli T, Fallgatter A, Lesch KP (2007) Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral Cortex 17:1160-1163

  7. Selch S, Haderlein J, Strobel A, Meyer J, Jacob CP, Schmitt A, Lesch KP, Reif A (2007) MLC1 polymorphisms are specifically associated with periodic catatonia, a sub-group of chronic schizophrenia. Biol Psychiatry 61:1211-1214

  8. Kraus MR, Al-Taie O, Schäfer A, Pfersdorff M, Lesch KP, Scheurlen M, (2007) Serotonin-1A receptor gene (HTR1A) variation predicts interferon-induced depression in chronic hepatitis C. Gastroenterology 132:1279-1286

  9. Müller J, Dreisbach G, Brocke B, Lesch KP, Strobel A, Goschke T (2007) Dopamine and cognitive control: The influence of spontaneous eyeblink rate, DRD4 exon III and gender on flexibility in set-shifting. Brain Res 1131:155-162

  10. Schimmelmann BG, Friedel S, Dempfle A, Warnke A, Lesch KP, Walitza, Renner T, Romanos M, Herpertz-Dahlmann B, Linder M, Schäfer H, Seitz C, Palmason H, Freitag C, Meyer J, Konrad K, Hinney A, Hebebrand J (2007) No evidence for preferential transmission of common valine66 allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. J Neural Transm 114:523-526

  11. Wellman CL, Izquierdo A, Garrett JE, Carroll J, Millstein R, Lesch KP, Murphy DL, Holmes A (2007) Maladaptive responses to emotional trauma and altered prefrontal  morphology in mice lacking the serotonin transporter. J Neurosci 27:684-691

  12. Hünnerkopf R, Strobel A, Gutknecht L, Brocke B, Lesch KP (2007) Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharmacol 32:2552-2560

  13. Trigo JM, Renoir, T, Lanfumey L, Hamon M, Lesch KP, Robledo P, Maldonado R (2007) 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biol Psychiatry 62:669-796

  14. Schmitt A, Benninghoff J, Mössner R,  Doenitz C, Gross S, Hermann M, Rizzi M, Gritti A, Lanfumey L, Fritzen S, Reif A, Hamon M, Murphy DL, Vescovi A, Lesch KP (2007) Adult neurogenesis in serotonin transporter deficient mice. J Neural Transm 114:1107-1119

  15. Friedel S, Saar K, Sauer S, Dempfle A, Walitza S, Renner T, Romanos M, Freitag C, Seitz C, Palmason H, Scherag A, Windemuth-Kieselbach C, Schimmelmann BG, Wewetzer C, Meyer J, Warnke A, Lesch KP, Reinhardt R, Herpertz-Dahlmann B, Linder M, Hinney A, Remschmidt H, Dupuis J, Schäfer H, Konrad K, Hubner N, Hebebrand J (2007) Association and linkage of allelic variants of the dopamine transporter gene in ADHD. Mol Psychiatry 12:23-33

  16. Reif A, Rösler M, Freitag CM, Schneider M, Eujen A, Kissling C, Wenzler D, Jacob CP, Retz-Junginger P, Thome J, Lesch KP, Retz W (2007) Nature and nurture predispose to violent behavior: on serotonergic genes and adverse childhood environment. Neuropsychopharmacology, Mar 7 [Epub ahead of print]

  17. Fritzen S, Lauer M, Schmitt A, Töpner T, Strobel A, Lesch KP, Reif A (2007) NO synthase-positive striatal interneurons are decreased in schizophrenia. Eur Neuropsychopharmacol 17:595-599

  18. Mössner R, Döring N, Scherag A, Schäfer H, Herpertz-Dahlmann B, Remschmidt H, Schulz E, Renner T, Wewetzer C, Warnke A, Lesch KP, Walitza S (2007) Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive-compulsive disorder. J Psychopharmacol, Jan 26 [Epub ahead of print]

  19. Fritzen S, Schmitt A, Köth K, Sommer C, Lesch KP, Reif A (2007) Neuronal nitric oxide synthase (NOS-I) knockout increases survival rate of neural cells in the hippocampus independently of BDNF Mol Cell Neurosci 5:261-271

  20. Marziniak M, Mössner R, Kienzler C, Riederer P, Lesch KP, Sommer C (2007) Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs. J Neural Transm 114:1227-1232

  21. Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schäfer H, Schmidtke A, Böning J, Lesch KP (2007) Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 257:309-317

  22. Reif A, Melchers M, Strobel A, Jacob CP, Herterich S, Lesch KP, Zimmer M (2007) FZD3 is not a risk gene for schizophrenia: a case-control study in a Caucasian sample. J Neural Transm Suppl. 72:297-301

  23. Numachi Y, Ohara A, Yamashita M, Fukushima S, Kobayashi H, Hata H, Watanabe H, Hall FS, Lesch KP, Murphy DL, Uhl GR, Sora I (2007) Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol 572:20-28

  24. Canli T, Lesch KP (2007) Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neurosci 10:1103-1109 IF 14.8

  25. Herrmann MJ, Walter A, Schreppel T, Ehlis AC, Pauli, Lesch KP, Fallgatter AJ (2007) D4 receptor gene variation modulates activation of prefrontal cortex during working memory. Eur J Neurosci 26:2713-2718

  26. Wultsch T, Chourbaji S, Fritzen S, Kittel S, Grünblatt E, Gerlach M, Gutknecht L, Chizat F, Golfier G, Schmitt A, Gass P, Lesch KP, Reif A. (2007) Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals. J Neural Transm Suppl. 72:69-85 

  27. Müller J, Dreisbach G, Goschke T, Hensch T, Lesch KP, Brocke B (2007) Dopamine and cognitive control: The prospect of monetary gains influences the balance between flexibility and stability in a set-shifting paradigm. Eur J Neurosci (im Druck)

  28. Strobel A, Dreisbach G, Müller J, Goschke T, Brocke B, Lesch KP (2007) Genetic variation of serotonin function and cognitive control. J Cogn Neurosci, Sep 24 [Epub ahead of print]

  29. Reif A, Schmitt A, Fritzen S, Lesch KP (2007) Neurogenesis and schizophrenia: dividing neurons in a divided mind? Eur Arch Psychiatry Clin Neurosci 257:290-299

  30. Lesch KP (2007) Linking emotion to the social brain: the role of the serotonin transporter in human social behaviour. EMBO reports 8:S24-29

  31. Fox MA, Andrews AM, Wendland JR, Lesch KP, Holmes A, Murphy DL (2007) A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology 95:147-166

  32. Murphy DL, Lesch KP (2007) Gene-targeted serotonin transporter, a murine protean pleiotropy model problem for human neurobiology and evolutionary genetics. Nat Rev Neurosci (im Druck)
  33. Jacob CP, Lesch KP (2007) Neurobiologie der Komorbidität des ADHS. In: Freitag CM, Retz W (Eds.) ADHS und komorbide Erkrankungen. Kohlhammer, Stuttgart pp. 15-27