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Publikationen 1998

Publications 1998


  1. Spurlock G, Heils A, Holman P, Williams J, D'Souza UM, Cardno A, Murphy KC, Jones L, Buckland PR, McGuffin P, Lesch KP, Owen MJ (1998) A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry 3:42-49
  2. Heils A, Wichems C, Mössner R, Petri S, Glatz K, Bengel D, Riederer P, Murphy DL, Lesch KP (1998) Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons. J Neurochem 40:932-939
  3. Bengel D, Balling U, Stöber G, Seemann M, Teufel, A, Li SH, Ross CA, Franzek E, Beckmann H, Riederer P, Lesch KP (1998) Susceptibility to catatonia, a subtype of schizophrenia, is not influenced by variation at the B33 CTG repeat locus. Eur Arch Psychiat Clin Neurosci 248:78-81
  4. Bengel D, Murphy DL, Andrews AM, Wichems CH, Feltner D, Heils A, Mössner R, Westphal H, Lesch KP (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-Methylenediosymethamphetamine ("ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol 53:649-655
  5. Stöber G, Jatzke S, Heils A, Jungkunz G, Fuchs E, Knapp M., Riederer P, Lesch KP (1998) Susceptibility for schizophrenia ist not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene. Eur Arch Psychiat Clin Neurosci 248:82-86
  6. Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H, Schmidt LG (1998) Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry 43:908-912
  7. Sora I, Wichems C, Takahashi N, Li XF, Revay R, Zeng Z, Lesch KP, Murphy DL, Uhl GR (1998) Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA 95:7699-7704
  8. Stöber G, Jatzke S, Heils A, Jungkunz G, Knapp M., Mössner R, Riederer P, Lesch KP (1998) Insertion/deletion variant (-141CIns/Del) in the 5' regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar disorder. J Neural Transm 105:101-109
  9. Türker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schütz H, Weiler G, Stöber G (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248:147-150
  10. Okladnova O, Syagailo YV, Tranitz M, Stöber G, Riederer P, Mössner R, Lesch KP (1998) A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain. Biochem Biophys Res Comm 248:402-405
  11. Heinze A, Higley JD, Gorey JG, Saunders R, Jones DW, Saunders R, Zajicek K, Suomi SJ, Lesch KP, Weinberger DR, Linnoila M (1998) In vivo association between alcohol intoxication, aggression and serotonin transporter availability in non-human primates. Am J Psychiatry 155:1023-1028
  12. Lesch KP (1998) Hallucinations: psychopathology meets functional genomics. Mol. Psychiatry 3:278-281
  13. Mössner R, Heils A, Okladnova O, Daniel S, Lesch KP (1998) Enhancement of serotonin transporter function by tumor necrosis factor alpha but not interleukin-6. Neurochem Int 33:251-254
  14. Okladnova O, Syagailo YV, Mössner R, Riederer P, Lesch KP (1998) Regulation of human PAX-6 gene transcription: alternate promoter usage in human brain. Mol Brain Res 60:177-192
  15. Bengel D, Isaacs KR, Heils, A, Lesch KP, Murphy DL (1998) The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells. Neuroreport 9:2989-2993
  16. Meyer J, Wiedemann P, Okladnova O, Brüss M, S´taab T, Stöber G, Riederer P, Bönisch H, Lesch KP (1998) Cloning and functional characterization of the human norepinephrine transporter gene promoter. J Neural Transm 105:1341-1350
  17. Stöber G, Jatzke S, Meyer J, Okladnova O, Knapp M, Beckmann H, Lesch KP (1998) Short CAG repeats within the hSKCa3 gene associated with schizophrenia: results of a family-based study. Neuroreport 9:3395-3599
  18. Benjamin J, Ebstein R, Lesch KP (1998) Genes for normal personality traits: implications for psychopathology. Int J Neuropsychopharm 1:153-168
  19.  Lesch KP (1998) Serotonin transporter and psychiatric disorders: listening to the gene. Neuroscientist 4:25-34
  20. Mössner R, Lesch KP (1998) Knockout mice in neuropsychopharmacology: present and future. Int J Neuropsychopharmacol 1:87-92
  21. Lesch KP, Mössner R (1998) Geneticaly driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders. Biol Psychiatry 44:179-192
  22. Lesch KP (1998) Gene transfer to the brain: emerging therapeutic strategy in psychiatry? Biol Psychiatry 45:247-253
  23. Mössner R, Lesch KP (1998) Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immunity 12:249-271
  24.  Lesch KP, Heils A, Bengel D (1998) Genetics of the 5-HT transporter: allelic variation in functional expression affects anxiety- and depression-related personality traits and susceptibility to affective disorders. In: Wahlström J. Genetics and Psychiatric disorders. Wenner-Gren International Series, Vol. 69, Pergamon Press, New York, pp 105-122