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Publikationen 2005

Publications 2005


  1. Marziniak M, Mössner R, Schmitt A, Lesch KP, Sommer C (2005) A polymorphism of the serotonin transporter gene is associated with migraine with aura. Neurology 64:157-159
  2. Mössner R, Weichselbaum A, Marziniak M, Freitag C, Lesch KP, Sommer C, Meyer J (2005) A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine with and without aura. Headache 45:132-136
  3. Newman TK, Syagailo Y, Barr CS, Wendland J, Champoux M, Grässle M, Suomi SJ, Higley JD, Lesch KP (2005) Monoamine oxidase A gene promoter polymorphism and infant rearing experience interact to influence aggression and injuries in rhesus monkeys. Biol Psychiatry 57:167-172
  4. McKeane DP, Meyer J, Dobrin SE, Melmed KM, Ekawardhani S, Tracy NA, Lesch KP, Stephan DA (2005) No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families. Schizophr Res 75:1-3
  5. Dreisbach G, Müller J Strobel A, Schulze K, Lesch KP, Brocke B, Goschke T (2005) Dopamine and cognitive control: The influence of spontaneous eye-blink rate and dopamine gene polymorphisms on perseveration and distractibility. Behavioral Neurosci 119:483-490
  6. Mössner R, Walitza S, Lesch KP, Geller F, Barth N, Remschmidt H, Hahn F, Herpertz-Dahlmann B, Fleischhaker C, Schulz E, Warnke A, Hinney A, Wewetzer C (2005) Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder. Int J Neuropsychopharmacol. 8:133-136
  7. Mössner R, Walitza S, Geller F, Scherag A, Gutknecht L, Bogusch L, Remschmidt H, Simons M, Herpertz-Dahlmann B, Fleischhaker C, Schulz E, Warnke A, Hinney A, Wewetzer C, Lesch KP (2005) Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int J Neuropsychopharamcol 9:437-442
  8. Asan E, Yilmazer-Hanke DM, Eliava M, Hantsch M, Lesch KP, Schmitt A (2005) The corticotropin-releasing factor (CRF)-system and monoaminergic afferents in the central amygdala: investigations in different mouse strains and comparison with the rat. Neuroscience 131:953-967
  9. Ren-Patterson, RF Cochran LW, Holmes A, Cheplo S, Huang SJ, Tolliver T, Lesch KP, Lu B, Murphy DL (2005) Gender-dependent reductions in brain monoamines and increased anxiety behaviors in BDNF plus serotonin transporter deficient mice. J Neurosci Res 79:756-771
  10. Reif A, Pfuhlmann B, Strobel A, Lesch KP (2005) Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses. Prog Neuropsychopharmacol Biol Psychiatry 28:1061-1063
  11. Canli T, Omura K, Haas B, Constable RT, Lesch KP (2005) Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci USA 102:12224-12229
  12. Jacob CP, Müller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, Schmidtke AS, Mössner R, Lesch KP (2005) Cluster B personality disorders are associated with allelic variation of MAOA activity. Neuropsychopharmacology 30:1711-1718
  13. Meyer J, Johannssen K, Freitag CM, Schraut K, Athanassiadou Z, Teuber I, Hahner A, Mainhardt C, Mössner R, Volz HP, Wienker T, McKeane D, Stephan DA, Rouleau G, Reif A, Lesch KP (2005) Rare variants of the gene encoding the potassium-chloride cotransporter 3, implicated in corpus callosum agenesis, are associated with psychoses of the schizophrenic and bipolar spectrum. Int J Neuropsychopharmacol 8:495-504
  14. Walitza S, Renner T, Dempfle A, Wewetzer C, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Linder M, Knölker U, Schäfer H, Gross C, Hebebrand J, Warnke A, Lesch KP (2005)  Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry 10:1126-32
  15. Hofstetter HH, Mössner R, Lesch KP, Linker RA, Toyka KV, Gold R (2005) Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease  and neuroantigen-specific interferon-gamma production in mouse EAE Clin Exp Immunology 142:1479-1485
  16. Kim DK, Tolliver TJ, Huang SJ, Martin BJ, Andrews AM, Wichems C, Holmes A, Lesch KP, Murphy DL (2005) Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 49:798-810
  17. Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP (2005) Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112:1479-1485
  18. Lesch KP, Gutknecht L (2005) Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 29:1062-1073
  19. Lesch KP (2005) Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link? Eur J Pharmacol 526:113-124
  20. Lesch KP (2005) Neurogenomics of depression. In: Licinio J, Wong ML (Eds.) Biology of Depression: From Novel Insights to Therapeutic Strategies. Vol. 2, Wiley-VCH, Weinheim, pp 713-732
  21. Lesch KP (2005) Genetic alterations of the murine serotonergic gene pathway: the neurodevelopmental basis of anxiety. In: Holsboer F, Ströhle A. Handbook of Experimental Pharmacology. Vol. 169, Anxiety and anxiolytic drugs. Springer, Berlin, Heidelberg, New York pp 71-112
  22. Lesch KP (2005) Serotonergic gene inactivation in mice: models for anxiety and aggression? The molecular mechanisms of aggressive behaviour. Wiley, Chichester (Novartis Foundation Symposium 268) pp 111-146