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Publikationen 2003

Publications 2003


  1. Vogel C, Mössner R, Gerlach M, Heinemann T, Murphy DL, Riederer P, Lesch KP, Sommer C (2003) Role of serotonin in neuropathic pain: Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci 23:708-715
  2.  Wisor J.P., Wurts S.W., Hal l F.S., Lesch K.P., Murphy D.L., Uhl G.R., Edgar D.M. (2003) Altered rapid eye movement (REM) sleep timing and REM-related EEG spectra in serotonin transporter knockout mice. Neuroreport 14:233-238.
  3.  Strobel A, Debener S, Schmidt D, Hünnerkopf R, Lesch KP, Brocke B (2003) Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential. Am J Med Genetics 118:41-47
  4.  Persico AM, Baldi A, Dell’Acqua ML, Mössner R, Murphy DL, Lesch KP, Keller F (2003) Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport 14:341-344
  5. Strobel A, Lesch KP, Jatzke S, Paetzold F, Brocke B (2003) Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants. Mol Psychiatry 8:371-2
  6. Strobel A, Frank M. Spinath FM, Angleitner A, Riemann R, Lesch KP (2003) Lack of association between polymorphisms of the dopamine D4 receptor gene and personality. Neuropsychobiology 47:52-56
  7. Steinke V, Meyer J, Syagailo YV, Ortega G, Hameister H, Schmitt A, Lesch KP (2003) The genomic organization of the murine Kiaa0027 (Wkl1, Mlc1) gene. J Neural Transm 110: 333–343
  8. Meyer J, Rüschendorf F, Lesch KP (2003) A second large family with catatonic schizophrenia supports the region distally of CHRNA7 on chromosome 15q14-15. Mol Psychiatry 8:259-260
  9. Barr CS, Newman TK, Becker ML, Champoux M, Lesch KP, Suomi SJ, Goldman D, Higley JD (2003) Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol Clin Exp Res 27:812-817
  10. Kelai S, Aissi F, Lesch KP, Cohen-Salmon C, Hamon M, Lanfumey L (2003) Alcohol intake after serotonin transporter inactivation in mice. Alcohol Alcohol 38:386-389
  11. Glatz K, Mössner R, Heils A, Lesch KP (2003) Glucocorticoid-induced expression of human serotonin transporter (5-HTT) is differentially regulated by the 5-HTT gene-linked polymorphic region. J Neurochem 86:1072-1078
  12. Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL (2003) Mice lacking the serotonin transporter exhibit 5-HT1A receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 28:2077-2088
  13. Schmitt A, Gofferje V, Weber M, Meyer J, Mössner R, Lesch KP (2003). The brain-specific protein MLC1 implicated in megalencephalic leucoencephalopathy with subcortical cysts is expressed in glial cells in the murine brain. Glia 44:283-295
  14. Barr CS, Newman TK, Becker ML, Parker C, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD (2003) The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2:336-340
  15. Strobel A, Gutknecht L, Rothe C, Reif A, Mössner R, Zeng Y, Brocke B, Lesch KP (2004) Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110:1445–1453
  16. Bouali S, Evrard A, Chastanet M, Lesch KP, Hamon M, Adrien J (2003) Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter. Eur J Neurosci. 2003 18:2203-2212
  17. Murphy DL, Uhl G, Holmes A, Ren-Patterson R, Hall FS, Sora I, Detera-Wadleigh S, Lesch KP (2003) Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes Brain Behav 2:350-364
  18. Gross J, Grimm O, Meyer J, Lesch KP (2003) Die Cadherin-Hypothese schizophrener Erkrankungen. Fortschr Neurol Psychiat 71:84-88.
  19. Reif A, Lesch KP (2003) Toward a molecular architecture of personality. Behav Brain Res 139:1-20
  20. Kamolz S, Jacob C, Lesch KP Pfuhlmann B, Reif A, Keller H, Wiesbeck GA (2003) Posttraumatic stress disorder – an overview. Krankenhauspsychiatrie 14:113-118
  21. Lesch KP, Zeng Y, Reif A, Gutknecht L (2003) Anxiety-related traits in mice with modified genes of the serotonergic pathway. Eur J Pharmacol 480:185-204
  22. Di Pino G, Mössner R, Lesch KP, Lauder JM, Persico AM (2003) Serotonin roles in neurodevelopment: more than just neural transmission. Curr Neuropharmacol (in press)
  23. Lesch KP (2003) Genetic dissection of anxiety and related disorders. In: Nutt D, Ballenger T (Eds.) Anxiety Disorders. Blackwell, Oxford, pp 229-250
  24. Lesch KP (2003) The serotonergic dimension of aggression and violence. Mattson MP (Ed.) Neurobiology of Aggression: Understanding and Preventing Violence. Humana Press, Totowa, NJ, pp. 33-63
  25. Lesch KP, Murphy DL (2003) Molecular genetics of transporters for norepinephrine, dopamine, and serotonin in behavioral traits and complex diseases. Bröer S, Wagner CA (eds) Membrane transport diseases: Molecular basis of inherited transport defects. Kluwer Academic/Plenum, New York pp 349-364